Description
Pleckstrin homology domain-containing family A member 5, also called Phosphoinositol 3-phosphate-binding protein 2 (PEPP-2) is a protein that in humans is encoded by the PLEKHA5 gene. This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules and is concentrated at the leading edge of migratory cells